Scientific Contributions Vascular Hypertrophy in Renal Hypertensive Spontaneously Hypertensive Rats

@inproceedings{Dilley2005ScientificCV,
  title={Scientific Contributions Vascular Hypertrophy in Renal Hypertensive Spontaneously Hypertensive Rats},
  author={Rodney James Dilley and Peter Kanellakis and Catherine J. Oddie and Alex Bobik},
  year={2005}
}
Vascular smooth muscle cells isolated from spontaneously hypertensive rats (SHR) replicate faster in vitro than do cells from Wistar-Kyoto (WKY) rats, suggesting that the vascular hypertrophy seen early in the life of SHR might be at least partially caused by abnormal cellular growth properties in vivo. To test whether specific growth stimuli produce more extensive hypertrophy in SHR than WKY rats, we compared their cardiovascular growth responses to two-kidney, one clip renal hypertension. Six… CONTINUE READING