Science to practice: can decreased lymph node MR imaging signal intensity be used as a biomarker for the efficacy of cancer vaccination?

Abstract

Summary In the study of Zhang et al (1), tumor-bearing mice were vaccinated with magnetically labeled, tumor antigen-primed dendritic cells (DCs). After homing of these antigen-presenting cells to the draining lymph node (LN), it was shown that the iron oxide-induced decrease in LN magnetic resonance (MR) imaging signal intensity correlated with the observed tumor growth delay, suggesting that the degree of hypointensity can serve as a surrogate marker for the efficacy of tumor vaccination.

DOI: 10.1148/radiol.14142331

Cite this paper

@article{Bulte2015ScienceTP, title={Science to practice: can decreased lymph node MR imaging signal intensity be used as a biomarker for the efficacy of cancer vaccination?}, author={Jeff W. M. Bulte}, journal={Radiology}, year={2015}, volume={274 1}, pages={1-3} }