Science review: Apoptosis in acute lung injury

  title={Science review: Apoptosis in acute lung injury},
  author={Gustavo Matute-Bello and Thomas R. Martin},
  journal={Critical Care},
  pages={355 - 358}
Apoptosis is a process of controlled cellular death whereby the activation of specific death-signaling pathways leads to deletion of cells from tissue. The importance of apoptosis resides in the fact that several steps involved in the modulation of apoptosis are susceptible to therapeutic intervention. In the present review we examine two important hypotheses that link apoptosis with the pathogenesis of acute lung injury in humans. The first of these, namely the 'neutrophilic hypothesis… CONTINUE READING