Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD–Dependent Manner

@article{Turbyville2010SchweinfurthinAS,
  title={Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD–Dependent Manner},
  author={T. Turbyville and D. B. G{\"u}rsel and R. Tuskan and J. Walrath and C. Lipschultz and S. Lockett and D. Wiemer and J. Beutler and K. Reilly},
  journal={Molecular Cancer Therapeutics},
  year={2010},
  volume={9},
  pages={1234 - 1243}
}
  • T. Turbyville, D. B. Gürsel, +6 authors K. Reilly
  • Published 2010
  • Biology, Medicine
  • Molecular Cancer Therapeutics
    • Neurofibromatosis type 1 (NF1) is the most common genetic disease affecting the nervous system. Patients typically develop many tumors over their lifetime, leading to increased morbidity and mortality. The NF1 gene, mutated in NF1, is also commonly mutated in sporadic glioblastoma multiforme (GBM). Because both NF1 and GBM are currently incurable, new therapeutic approaches are clearly needed. Natural products represent an opportunity to develop new therapies, as they have been evolutionarily… CONTINUE READING
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    References

    SHOWING 1-10 OF 64 REFERENCES
    Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation
    • 120
    • PDF
    Tumor microenvironment and neurofibromatosis type I: connecting the GAPs
    • 152
    • PDF
    Mouse models of tumor development in neurofibromatosis type 1.
    • 429
    Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
    • 544
    Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation
    • 166
    • PDF
    Neurofibromas in NF1: Schwann Cell Origin and Role of Tumor Environment
    • 522
    • PDF
    Tumorigenic properties of neurofibromin‐deficient Schwann cells in culture and as syngrafts in Nf1 knockout mice
    • 23
    Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
    • 571
    • PDF
    Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
    • 357
    Recent developments in neurofibromatosis type 1
    • 94
    • PDF