Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD–Dependent Manner

@article{Turbyville2010SchweinfurthinAS,
  title={Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD–Dependent Manner},
  author={T. Turbyville and D. B. G{\"u}rsel and R. Tuskan and J. Walrath and C. Lipschultz and S. Lockett and D. Wiemer and J. Beutler and K. Reilly},
  journal={Molecular Cancer Therapeutics},
  year={2010},
  volume={9},
  pages={1234 - 1243}
}
  • T. Turbyville, D. B. Gürsel, +6 authors K. Reilly
  • Published 2010
  • Biology, Medicine
  • Molecular Cancer Therapeutics
  • Neurofibromatosis type 1 (NF1) is the most common genetic disease affecting the nervous system. Patients typically develop many tumors over their lifetime, leading to increased morbidity and mortality. The NF1 gene, mutated in NF1, is also commonly mutated in sporadic glioblastoma multiforme (GBM). Because both NF1 and GBM are currently incurable, new therapeutic approaches are clearly needed. Natural products represent an opportunity to develop new therapies, as they have been evolutionarily… CONTINUE READING
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