Schwann cells seeded in acellular nerve grafts improve functional recovery.

  title={Schwann cells seeded in acellular nerve grafts improve functional recovery.},
  author={Nithya J Jesuraj and Katherine B Santosa and Matthew MacEwan and Amy Marie Moore and Rahul Kasukurthi and Wilson Z Ray and Eric R Flagg and Daniel A. Hunter and Gregory H. Borschel and Philip James Johnson and Susan E. Mackinnon and Shelly E Sakiyama-Elbert},
  journal={Muscle & nerve},
  volume={49 2},
INTRODUCTION This study evaluated whether Schwann cells (SCs) from different nerve sources transplanted into cold-preserved acellular nerve grafts (CP-ANGs) would improve functional regeneration compared with nerve isografts. METHODS SCs isolated and expanded from motor and sensory branches of rat femoral and sciatic nerves were seeded into 14mm CP-ANGs. Growth factor expression, axonal regeneration, and functional recovery were evaluated in a 14-mm rat sciatic injury model and compared with… CONTINUE READING
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