Schwann cells express NDF and SMDF/n-ARIA mRNAs, secrete neuregulin, and show constitutive activation of erbB3 receptors: evidence for a neuregulin autocrine loop.

@article{Rosenbaum1997SchwannCE,
  title={Schwann cells express NDF and SMDF/n-ARIA mRNAs, secrete neuregulin, and show constitutive activation of erbB3 receptors: evidence for a neuregulin autocrine loop.},
  author={C L Rosenbaum and Saikumar Karyala and Mark A. Marchionni and Haesun Kim and Alexei L. Krasnoselsky and Brigitte Happel and I. M. Isaacs and Robert Brackenbury and Nancy Ratner},
  journal={Experimental neurology},
  year={1997},
  volume={148 2},
  pages={604-15}
}
Cultured Schwann cells secreted low levels (30 pg/ml/1.5 x 10(6) cells) of a 45-kDa neuregulin protein and showed constitutive activation of a neuregulin receptor, Erb-B3, suggesting the existence of an autocrine loop involving neuregulins in Schwann cells. RT-PCR analyses indicated that Schwann cells and fibroblasts in culture produced SMDF/n-ARIA and NDF but not GGF neuregulin messages. Schwann cell and fibroblast neuregulin messages encoded both beta and alpha domains; Schwann cell… CONTINUE READING

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