Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus.

@article{Canto1980SchwannCR,
  title={Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus.},
  author={Mauro C Dal Canto and Howard L. Lipton},
  journal={The American journal of pathology},
  year={1980},
  volume={98 1},
  pages={101-22}
}
Theiler's murine encephalomyelitis virus (TMEV) infection produces a chronic demyelinating disease in mice, and myelin breakdown appears to be immune-mediated. By using an attenuated TMEC strain, WW virus, to infect mice, the course of the disease was slowed and the severity of the inflammatory and glial responses were reduced. In this circumstance, most of the demyelinating lesions showed extensive remyelination, predominantly by Schwann cells. In addition, it was demonstrated that there was… CONTINUE READING

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