Schwann cell myelination.

  title={Schwann cell myelination.},
  author={James L. Salzer},
  journal={Cold Spring Harbor perspectives in biology},
  volume={7 8},
Myelinated nerve fibers are essential for the rapid propagation of action potentials by saltatory conduction. They form as the result of reciprocal interactions between axons and Schwann cells. Extrinsic signals from the axon, and the extracellular matrix, drive Schwann cells to adopt a myelinating fate, whereas myelination reorganizes the axon for its role in conduction and is essential for its integrity. Here, we review our current understanding of the development, molecular organization, and… CONTINUE READING
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