Schwann cell myelination occurred without basal lamina formation in laminin alpha2 chain-null mutant (dy3K/dy3K) mice.

@article{Nakagawa2001SchwannCM,
  title={Schwann cell myelination occurred without basal lamina formation in laminin alpha2 chain-null mutant (dy3K/dy3K) mice.},
  author={Masafumi Nakagawa and Yuko Miyagoe-Suzuki and Koji Ikezoe and Yasuhiko Miyata and Ikuya Nonaka and Kiyonori Harii and Shin'ichi Takeda},
  journal={Glia},
  year={2001},
  volume={35 2},
  pages={101-10}
}
The laminin alpha2 chain is a major component of basal lamina in both skeletal muscle and the peripheral nervous system. Laminin alpha2 chain deficiency causes merosin-deficient congenital muscular dystrophy, which affects not only skeletal muscles, but also the peripheral and central nervous systems. It has been reported that the formation of basal lamina is required for myelination in the peripheral nervous system. In fact, the spinal root of dystrophic mice (dy/dy mice), whose laminin alpha2… CONTINUE READING
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