Schwann cell autophagy counteracts the onset and chronification of neuropathic pain

@article{Marinelli2014SchwannCA,
  title={Schwann cell autophagy counteracts the onset and chronification of neuropathic pain},
  author={Sara Marinelli and Francesca Nazio and Antonella Tinari and Laura Ciarlo and Flaminia Pavone},
  journal={PAIN®},
  year={2014},
  volume={155},
  pages={93-107}
}
Axonal degeneration in peripheral nerves after injury is accompanied by myelin degradation initiated by Schwann cells (SCs). These cells activate autophagy, a ubiquitous cytoprotective process essential for degradation and recycling of cellular constituents. Concomitantly to nerve insult and axonal degeneration, neuropathic pain (NeP) arises. The role of SC autophagy in the mechanisms underlying NeP is still unknown. In this study, we examined the role of the autophagy during the early phase of… CONTINUE READING
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