Schwangerschaftsprotein 1 (SP1) as a maternal serum marker for Down syndrome in the first and second trimesters.

@article{Qin1997Schwangerschaftsprotein1,
  title={Schwangerschaftsprotein 1 (SP1) as a maternal serum marker for Down syndrome in the first and second trimesters.},
  author={Q P Qin and Michael Christiansen and Tri Huu Nguyen and Steen Mellerup S\orensen and Severin Olesen Larsen and Bent N\orgaard-Pedersen},
  journal={Prenatal diagnosis},
  year={1997},
  volume={17 2},
  pages={101-8}
}
The potential of the maternal serum concentration of schwangerschaftsprotein 1 (MSSP1) as a marker for Down syndrome (DS) pregnancies was evaluated in the fifth to the 20th gestational week using 156 DS pregnancies and 546 unaffected control pregnancies. In DS pregnancies, the median of the multiple of the median (MOM) of MSSP1 was 0.27 [95 per cent confidence interval (CI) 0.11-0.59] in weeks 5-9 (n = 25) and 1.28 (CI 1.11-1.49) in weeks 14-20 (n = 117), significantly different from controls… CONTINUE READING

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