Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele.

@article{Schrhoff2007SchizotypalDA,
  title={Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele.},
  author={Franck Sch{\"u}rhoff and Andrei Sz{\"o}ke and Fabien Le Chevalier and Isabelle Roy and Alexandre M{\'e}ary and Frank Bellivier and Bruno Giros and Marion Leboyer},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2007},
  volume={144B 1},
  pages={64-8}
}
BACKGROUND Although catechol-O-methyltransferase (COMT) has long been suggested to be implicated in the pathogenesis of schizophrenia, association studies have generated discrepant results concerning the involvement of the COMT gene in schizophrenia. As several studies have suggested that schizotypal traits might be genetically related to schizophrenia, increased statistical power to detect gene effects could be obtained by using dimensional personality traits in unaffected relatives. METHODS… CONTINUE READING

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