Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism.

@article{Britto2016SchizosaccharomycesPK,
  title={Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism.},
  author={Mishan Britto and Adeline Goulet and Syeda Gazala Rizvi and Ottilie von Loeffelholz and Carolyn A Moores and Robert Anthony Cross},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 47},
  pages={E7483-E7489}
}
Cut7, the sole kinesin-5 in Schizosaccharomyces pombe, is essential for mitosis. Like other yeast kinesin-5 motors, Cut7 can reverse its stepping direction, by mechanisms that are currently unclear. Here we show that for full-length Cut7, the key determinant of stepping direction is the degree of motor crowding on the microtubule lattice, with greater crowding converting the motor from minus end-directed to plus end-directed stepping. To explain how high Cut7 occupancy causes this reversal, we… CONTINUE READING
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