Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.

@article{Sommariva2005SchizosaccharomycesPS,
  title={Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.},
  author={Elena Sommariva and Till K. Pellny and Nilay Demirkol Karahan and S. Kiran Kumar and Joel A. Huberman and J. Z. Dalgaard},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 7},
  pages={2770-84}
}
The Swi1 and Swi3 proteins are required for mat1 imprinting and mating-type switching in Schizosaccharomyces pombe, where they mediate a pause of leading-strand replication in response to a lagging-strand signal. In addition, Swi1 has been demonstrated to be involved in the checkpoint response to stalled replication forks, as was described for the Saccharomyces cerevisiae homologue Tof1. This study addresses the roles of Swi1 and Swi3 during a replication process perturbed by the presence of… CONTINUE READING

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