Schizophrenia risk from complex variation of complement component 4

  title={Schizophrenia risk from complex variation of complement component 4},
  author={Aswin Sekar and Allison Rosen Bialas and Heather de Rivera and Avery Davis and Timothy R. Hammond and Nolan Kamitaki and Katherine Tooley and Jessy Presumey and Matthew A Baum and Vanessa E Van Doren and Giulio Genovese and Samuel A. Rose and Robert E. Handsaker and Mark J. Daly and Michael C Carroll and Beth Stevens and Steven A. McCarroll},
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia’s strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in part from many structurally diverse alleles of the complement component 4 (C4) genes. We found that these alleles generated widely varying… CONTINUE READING
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