Schizophrenia-like deficits in auditory P1 and N1 refractoriness induced by the psychomimetic agent phencyclidine (PCP).

@article{Javitt2000SchizophrenialikeDI,
  title={Schizophrenia-like deficits in auditory P1 and N1 refractoriness induced by the psychomimetic agent phencyclidine (PCP).},
  author={D. C. Javitt and M. R. Jayachandra and Robert W. Lindsley and Colleen M Specht and Charles E. Schroeder},
  journal={Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
  year={2000},
  volume={111 5},
  pages={833-6}
}
OBJECTIVES The amplitude of the cortically generated auditory event-related potential (ERP) components P1 and N1 decreases as the interval between successive stimuli (ISI) decreases. Although the phenomenon of P1 and N1 refractoriness is well established, the underlying mechanisms are poorly understood. The present study investigates P1 and N1 refractoriness in the awake monkey in order to investigate underlying mechanisms. METHODS Auditory ERP were obtained in response to repetitive auditory… CONTINUE READING