Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition

@article{Starc2017SchizophreniaIA,
  title={Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition},
  author={Martina Starc and John D Murray and Nicole Santamauro and Aleksandar Savi{\'c} and Alan Anticevic},
  journal={Schizophrenia Research},
  year={2017},
  volume={181},
  pages={107-116}
}
Schizophrenia is associated with severe cognitive deficits, including impaired working memory (WM). A neural mechanism that may contribute to WM impairment is the disruption in excitation-inhibition (E/I) balance in cortical microcircuits. It remains unknown, however, how these alterations map onto quantifiable behavioral deficits in patients. Based on predictions from a validated microcircuit model of spatial WM, we hypothesized two key behavioral consequences: i) increased variability of WM… CONTINUE READING
5
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

On the Short-Lived Nature of Working Memory: Drift and Decay in a Population-coding model.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Working memory impairments in schizophrenia: a meta-analysis.

  • Journal of abnormal psychology
  • 2005
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Cognition in schizophrenia: core psychological and neural mechanisms

  • Trends in Cognitive Sciences
  • 2012
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL