Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats

  title={Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats},
  author={Yuni Kay and Linda Tsan and Elizabeth A. Davis and Chen Tian and Lea Decarie-Spain and Anastasiia V Sadybekov and Anna N Pushkin and Vsevolod Katritch and Scott E. Kanoski and Bruce E Herring},
  journal={Nature Communications},
Mutations in the putative glutamatergic synapse scaffolding protein SAP97 are associated with the development of schizophrenia in humans. However, the role of SAP97 in synaptic regulation is unclear. Here we show that SAP97 is expressed in the dendrites of granule neurons in the dentate gyrus but not in the dendrites of other hippocampal neurons. Schizophrenia-related perturbations of SAP97 did not affect CA1 pyramidal neuron synapse function. Conversely, these perturbations produce dramatic… 
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