Schizophrenia and the gut–brain axis

  title={Schizophrenia and the gut–brain axis},
  author={Katlyn L Nemani and Reza Hosseini Ghomi and Beth A. McCormick and Xiaoduo Fan},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • K. Nemani, R. Ghomi, Xiaoduo Fan
  • Published 2 January 2015
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
The brain-gut axis dysfunctions and hypersensitivity to food antigens in the etiopathogenesis of schizophrenia.
Research results seem to be very promising and indicate the possibility of improved clinical outcomes in some patients with schizophrenia by modifying diet, use of probiotics, and the implementation of antibiotic therapy of specific treatment groups, however, further research is needed on links between the intestinal microbiome and intestinal function as factors mediating the activation of the immune system.
Stress and the Role of the Gut–Brain Axis in the Pathogenesis of Schizophrenia: A Literature Review
  • behnam vafadari
  • Psychology, Medicine
    International journal of molecular sciences
  • 2021
The main interest of this review article is in overviewing the major recent findings on the effects of stress and the gut–brain axis, as well as their possible bidirectional effects, in the pathogenesis of schizophrenia.
Gut microbiota: An intermediary between metabolic syndrome and cognitive deficits in schizophrenia
The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option
Despite the accumulated knowledge in this field, more studies are warranted and required to further the understanding of the brain-gut axis and the possibility of targeting microbiota as a treatment option for schizophrenia and major depressive disorder.
Gut-brain axis: A matter of concern in neuropsychiatric disorders…!
The gut microbiota is composed of a large number of microbes, usually regarded as commensal bacteria. It has become gradually clear that gastrointestinal microbiota affects gut pathophysiology and
Gut–Brain Axis: A New Revolution to Understand the Pathogenesis of Autism and Other Severe Neurological Diseases
The gut microbiota can modulate brain function, forming a crucial link in the bidirectional interactions between the intestine and the nervous system.
Interactions between the gut microbiome and the central nervous system and their role in schizophrenia, bipolar disorder and depression
The aim of this review is to summarize the recognized pathways of the gut–brain axis that have been thoroughly studied in animal models and to evaluate the role of the dialogue between the microbiota and the central nervous system in schizophrenia, bipolar disorder and depression.
Microbiota regulation of the Mammalian gut-brain axis.


Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
The new link between gut–brain axis and neuropsychiatric disorders
This review summarizes some recent findings that may localize the origin of eating disorders as well as some other neuropsychiatric disorders outside the brain and discuss their cause as a possible dysfunction of the gut–brain axis involving the humoral immune system.
Effect of intestinal microbial ecology on the developing brain.
A brief review of the intestinal microbiome is provided, with a focus on new studies showing that there is an important link between the microbes that inhabit the intestinal tract and the developing brain.
Autoimmune diseases and infections as risk factors for schizophrenia
Autoimmune diseases and infections should be considered in the treatment of individuals with schizophrenia symptoms, and further research is needed of the immune system's possible contributing pathogenic factors in the etiology of schizophrenia.
The role of microbes and autoimmunity in the pathogenesis of neuropsychiatric illness
  • M. Hornig
  • Biology, Medicine
    Current opinion in rheumatology
  • 2013
An increased prevalence of familial autoimmunity, exposure to pathogens prenatally and postnatally, and findings of antibrain antibodies is common in disorders as diverse as schizophrenia, obsessive-compulsive disorder and autism, and suggests that differences in exposure timing and genetic vulnerability toward autoimmonity are important determinants of neuropsychiatric outcomes.
Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat
The results suggest that the gut microbiome has a role in the cycle of metabolic dysfunction associated with olanzapine, and could represent a novel therapeutic target for preventing antipsychotic-induced metabolic disease.
The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia
Diet, microbiota and autoimmune diseases
It is hypothesize that the beneficial and life-prolonging effects of caloric restriction on a variety of autoimmune models including lupus might partly be mediated by its effects on the gut microbiome and associated virome, the collection of all viruses in the gut.