Schizophrenia and the disconnection hypothesis.

  title={Schizophrenia and the disconnection hypothesis.},
  author={Karl J. Friston},
  journal={Acta psychiatrica Scandinavica. Supplementum},
  • Karl J. Friston
  • Published 1999 in Acta psychiatrica Scandinavica. Supplementum
This article reviews the disconnection hypothesis of schizophrenia and presents a mechanistic account of how dysfunctional integration among neuronal systems might arise. This neurobiological account is based on some simple observations about schizophrenia and the central role that neuronal plasticity plays in shaping the connections, and the ensuing dynamics, that underlie brain function. The particular hypothesis put forward here is that the pathophysiology of schizophrenia is expressed at… CONTINUE READING

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