Schizophrenia and neurosurgery: A dark past with hope of a brighter future

  title={Schizophrenia and neurosurgery: A dark past with hope of a brighter future},
  author={Prateek Agarwal and Christina E. Sarris and Yehuda Herschman and Nitin Agarwal and Antonios Mammis},
  journal={Journal of Clinical Neuroscience},
Neurosurgery for Refractory Schizophrenia: A Systematic Literature Review
The results show that DBS has a promising future in the treatment of refractory schizophrenia, and the use of a stereotactic approach enables psychosurgery to be a safe and effective treatment option in cases of refracted schizophrenia, improving the quality of life and the symptoms.
Alternatives to Pharmacological and Psychotherapeutic Treatments in Psychiatric Disorders
This review presents the data as a comprehensive, narrative review about the role, indication, safety, and results of the contemporary instrumental techniques that opened new therapeutic fields for selected patients unresponsive to psychotherapy and pharmacotherapy.
Schizo-obsessive disorder and neurosurgery for schizophrenia
The overlap between schizophrenia, schizo-obsessive disorder and obsessive-compulsive disorder is discussed within the context of a clinical case and neuroimaging data, and the use of obsessive-Compulsive disorder deep brain stimulation protocols for schizophrenia is discussed and may yield an advance in neurosurgical treatment of psychiatric conditions.
Dr. Robert G. Heath: a controversial figure in the history of deep brain stimulation.
While distinction between the modern practice of DBS and its controversial origins is necessary, it is important to examine Dr. Heath's work as it allows for reflection on current neurosurgical practices and questioning the ethical implication of these advancements.
Target selection for deep brain stimulation in treatment resistant schizophrenia
Perspectives of neurosurgery for psychiatric disorders
Neurosurgical treatment for psychiatric disorders has been practically abandoned for a considerable period and is under strict control of the committees of Neurosurgery for psychiatric diseases of referral hospitals and submitted to strict legislation in most countries.
Thermocoagulation for the Treatment of Anorexia Nervosa Associated with Obsessive-Compulsive Disorder: Case Report
Follow-up, performed 16 months after the procedure, showed substantial improvement in AN, OCD, and schizophrenia symptoms, demonstrating the effectiveness of this type of intervention in patients refractory to conservative treatment.
A Roadmap for Development of Novel Antipsychotic Agents Based on a Risperidone Scaffold
A ROADMAP FOR DEVELOPMENT OF NOVEL ANTIPSYCHOTIC AGENTS BASED ON A RISPERIDONE SCAFFOLD By Urjita H. Shah, Ph. D. A dissertation submitted in partial fulfillment of the requirements for the degree of


Surgery for psychiatric disorders.
Antipsychotic treatment of schizophrenia: an update.
Pathophysiologic mechanisms in the pathogenesis and clinical course of schizophrenia.
  • J. Lieberman
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 1999
Evidence of neurodevelopmental and neurodegenerative mechanisms for the development of schizophrenia is presented and the importance of effective treatment at the first onset of schizophrenia to improve patient outcome is indicated.
Transcranial Direct Current Stimulation in Schizophrenia
This review summarizes the research work that has examined the effects of tDCS in schizophrenia patients with respect to symptom amelioration, cognitive enhancement and neuroplasticity evaluation and discusses the mechanistic aspects of the technique.
Animal models of schizophrenia
The review highlights the need to develop more comprehensive animal models that more adequately replicate deficits in negative and cognitive symptoms of schizophrenia, and identifies specific rodent behavioural tasks with translational relevance to specific cognitive domains affected in schizophrenia.
Potential surgical targets for deep brain stimulation in treatment-resistant depression.
Surgical intervention for TRD in the form of DBS is emerging as a viable treatment alternative to existing modalities and various surgical targets, such as the subgenual cingulate cortex, inferior thalamic peduncle, and nucleus accumbens, have been shown to be safe and to lead to beneficial effects with various stimulation parameters.
Neurosurgical treatment for refractory obsessive-compulsive disorder: implications for understanding frontal lobe function.
The authors update current stereotactic procedures and their efficacy, safety, and side effect profiles, and the design of an ongoing placebo-controlled trial of Gamma Knife capsulotomy for refractory OCD is outlined.