Schizophrenia and glutamatergic transmission.

  title={Schizophrenia and glutamatergic transmission.},
  author={Carol A. Tamminga},
  journal={Critical reviews in neurobiology},
  volume={12 1-2},
Schizophrenia is a human brain disease with well-defined symptoms and a lifelong disease course, but without a current biological explanation. Several observations implicate brain glutamatergic abnormalities in the pathophysiology of this illness. This evidence includes both human neurochemical and clinical pharmacologic data. Furthermore the psychotomimetic action of phencyclidine, the noncompetitive NMDA-sensitive glutamate receptor antagonist, suggests the association between human psychosis… CONTINUE READING
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