Schizophrenia, hypocretin (orexin), and the thalamocortical activating system.

@article{Lambe2007SchizophreniaH,
  title={Schizophrenia, hypocretin (orexin), and the thalamocortical activating system.},
  author={Evelyn K Lambe and R Liu and George K. Aghajanian},
  journal={Schizophrenia bulletin},
  year={2007},
  volume={33 6},
  pages={1284-90}
}
Diminished connectivity between midline-intralaminar thalamic nuclei and prefrontal cortex has been suggested to contribute to cognitive deficits that are detectable even in early stages of schizophrenia. The midline-intralaminar relay cells comprise the final link in the ascending arousal pathway and are selectively excited by the wake-promoting peptides hypocretin 1 and 2 (orexin A and B). This excitation occurs both at the level of the relay cell bodies and their axon terminals within… CONTINUE READING

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