Schizophrenia, Violence, Clozapine and Risperidone: a Review

@article{Delal1996SchizophreniaVC,
  title={Schizophrenia, Violence, Clozapine and Risperidone: a Review},
  author={Brian Delal and Bernard Huckstep and Emmet P. Larkin},
  journal={British Journal of Psychiatry},
  year={1996},
  volume={169},
  pages={21 - 30}
}
There is no longer much doubt that there is a small but real association between psychosis and violence directed at others, as well as between psychosis and self-directed violence, including suicide. Schizophrenia and the affective psychoses appear to have a similar order of association with suicide (Caldwell & Gottesman, 1990), but schizophrenia is more likely to be associated with serious other-directed violence. The evidence for the effect of schizophrenia comes from three main directions… 
17 Citations

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The reduction in violence and persistent aggression with clozapine treatment should improve the chances for integration of the schizophrenia patient into the community and provide cost savings to society.

Comparison of antipsychotic medication effects on reducing violence in people with schizophrenia

Effective antipsychotics are needed, but may not reduce violence unrelated to acute psychopathology, but not in patients with a history of childhood antisocial conduct.

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Depression and impulsivity are important predictors of aggression and of differential response to antiaggressive treatment and by identifying patients who will respond better to a given medication, they will be able to develop individualized strategies for the treatment of violent behavior.

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In the complex "real world" settings where persons with schizophrenia reside, long-term treatment with olanzapine confers some advantage over risperidone in reducing violence risk, at least in part an indirect effect, via improvement in adherence with treatment.

Effectiveness of atypical antipsychotic medications in reducing violent behavior among persons with schizophrenia in community-based treatment.

Treatment with atypical antipsychotic medications should be considered as an important component of violence risk management for schizophrenia patients at risk for violent behavior.

The Effect of Clozapine on the Social Behaviour Schedule in Patients Attending a Forensic Psychiatry Day Hospital

It was discovered that there was a marked difference in the hostility scores between clozapine patients and non-clozAPine patients, which scored higher in the category of other behaviours that might impede progress, particularly drug-taking.

Origins of Early Intervention in First-Episode Psychosis

The discovery of the antipsychotic drugs, the process of deinstitutionalization, and new conceptualizations of schizophrenia have been necessary precursors to current best practice treatments and have been complemented by the increasing influence of consumer and family advocacy groups, and government policy initiatives.

The role of typical and atypical antipsychotic medications in the management of agitation and aggression.

  • P. Buckley
  • Psychology, Medicine
    The Journal of clinical psychiatry
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Typical and atypical antipsychotics are indicated for persistent aggression in psychosis when medication noncompliance is the obstacle to effective treatment.

Clozapine in Special Hospital: a retrospective case-control study

The prescription of Clozapine to patients in Special Hospital leads to a greater likelihood of discharge to other services and this difference appears to be maintained over several years and to increase with time.

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