Schistosomes express two forms of cathepsin D.

  title={Schistosomes express two forms of cathepsin D.},
  author={J. Y. Wong and Stephe Harrop and Sharon R. Day and Paul J. Brindley},
  journal={Biochimica et biophysica acta},
  volume={1338 2},
We report here a cDNA and its deduced amino acid sequence encoding a cathepsin D-like, aspartic protease expressed by adult stages of the human blood fluke Schistosoma mansoni. The cDNA encodes a short signal peptide, a pro-enzyme peptide of 37 amino acid residues, and a mature enzyme of 377 residues which has strong homology with mammalian cathepsins D. This aspartic protease, although 84% identical in amino acids of the mature enzyme region to the previously reported cathepsin D from the… CONTINUE READING
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