Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells

@inproceedings{Vlugt2012SchistosomesIR,
  title={Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells},
  author={Luci{\"e}n E. P. M. van der Vlugt and Lucja A. Labuda and Arifa Ozir-Fazalalikhan and Ellen Lievers and Anouk K. Gloudemans and Kit-Yeng Liu and Tom Barr and Tim Sparwasser and Louis Boon and Ulysse Ateba Ngoa and Eliane Ngoune Feugap and Ay{\^o}la A. Adegnika and Peter Gottfried Kremsner and David Gray and Maria Yazdanbakhsh and Hermelijn H Smits},
  booktitle={PloS one},
  year={2012}
}
Chronic helminth infections, such as schistosomes, are negatively associated with allergic disorders. Here, using B cell IL-10-deficient mice, Schistosoma mansoni-mediated protection against experimental ovalbumin-induced allergic airway inflammation (AAI) was shown to be specifically dependent on IL-10-producing B cells. To study the organs involved, we transferred B cells from lungs, mesenteric lymph nodes or spleen of OVA-infected mice to recipient OVA-sensitized mice, and showed that both… CONTINUE READING
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