Schistosome satellite DNA encodes active hammerhead ribozymes.

@article{Ferbeyre1998SchistosomeSD,
  title={Schistosome satellite DNA encodes active hammerhead ribozymes.},
  author={Gerardo Ferbeyre and Joseph Mather Smith and Robert Cedergren},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 7},
  pages={
          3880-8
        }
}
Using a computer program designed to search for RNA structural motifs in sequence databases, we have found a hammerhead ribozyme domain encoded in the Smalpha repetitive DNA of Schistosoma mansoni. Transcripts of these repeats are expressed as long multimeric precursor RNAs that cleave in vitro and in vivo into unit-length fragments. This RNA domain is able to engage in both cis and trans cleavage typical of the hammerhead ribozyme. Further computer analysis of S. mansoni DNA identified a… CONTINUE READING

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