Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel.

@article{Kohn2001SchistosomeCC,
  title={Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel.},
  author={Andrea B. Kohn and Peter A. V. Anderson and Jessica M Roberts-Misterly and Robert M Greenberg},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 40},
  pages={36873-6}
}
Schistosomes are parasitic flatworms that cause schistosomiasis, a major tropical disease. The current drug of choice against schistosomiasis is praziquantel (PZQ), which has minimal side effects and is potent against all schistosome species. The mode of action of PZQ is unknown, though the drug clearly affects Ca(2+) homeostasis in worms, and there is indirect evidence for interaction of PZQ with schistosome voltage-gated Ca(2+) channels. We have cloned and expressed two Ca(2+) channel beta… CONTINUE READING

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