Schistosome N-glycans containing core alpha 3-fucose and core beta 2-xylose epitopes are strong inducers of Th2 responses in mice.

@article{Faveeuw2003SchistosomeNC,
  title={Schistosome N-glycans containing core alpha 3-fucose and core beta 2-xylose epitopes are strong inducers of Th2 responses in mice.},
  author={Christelle Faveeuw and Thierry Mallevaey and Katharina Paschinger and Iain B H Wilson and Josette Fontaine and Rosella Mollicone and Rosal{\'i}a Pedreny Oriol and Friedrich Altmann and Patrice Lerouge and Monique Capron and François Trottein},
  journal={European journal of immunology},
  year={2003},
  volume={33 5},
  pages={
          1271-81
        }
}
During murine schistosomiasis, egg-derived glycoconjugates play a key role in skewing the immune response towards a Th2 phenotype. Among the candidates responsible for this effect, complex-type N-glycans containing the core alpha 3-fucose and core beta 2-xylose determinants, two glycan epitopes found in some invertebrate- and plant-derived allergens, may be important. Here, we show that core alpha 3-fucose and core beta 2-xylose determinants are expressed in the different developmental stages… CONTINUE READING

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