Schistosoma mansoni major egg antigen Smp40: molecular modeling and potential immunoreactivity for anti-pathology vaccine development.

@article{AbouelNour2006SchistosomaMM,
  title={Schistosoma mansoni major egg antigen Smp40: molecular modeling and potential immunoreactivity for anti-pathology vaccine development.},
  author={Mohamed Fathy Abouel-Nour and Mahmoud Lotfy and Abdelfattah Mohamed Attallah and Barbara L Doughty},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2006},
  volume={101 4},
  pages={365-72}
}
The pathogenesis of Schistosoma mansoni infection is largely determined by host T-cell mediated immune responses such as the granulomatous response to tissue deposited eggs and subsequent fibrosis. The major egg antigens have a valuable role in desensitizing the CD4+ Th cells that mediate granuloma formation, which may prevent or ameliorate clinical signs of schistosomiasis.S. mansoni major egg antigen Smp40 was expressed and completely purified. It was found that the expressed Smp40 reacts… CONTINUE READING