Schistosoma mansoni host-exposed surface antigens characterized by sera and recombinant antibodies from schistosomiasis-resistant rats.

@article{Sepulveda2010SchistosomaMH,
  title={Schistosoma mansoni host-exposed surface antigens characterized by sera and recombinant antibodies from schistosomiasis-resistant rats.},
  author={Jorge L. Sepulveda and Jacqueline M. Tremblay and Jon P. DeGnore and Patrick Skelly and Charles B Shoemaker},
  journal={International journal for parasitology},
  year={2010},
  volume={40 12},
  pages={1407-17}
}
Antibodies from Schistosoma mansoni-infected rats, unlike mice, show a higher titer for schistosome apical tegumental antigens compared with non-apical membrane antigens. These antibodies bind to the surface of living lung-stage worms and to formaldehyde-fixed adult worms. We produced a single-chain antibody Fv domain (scFv) phage library displaying the antibody repertoire of rats highly immune to schistosome infection and we selected for scFvs that recognize the host-exposed surface of worms… CONTINUE READING
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Making sense of the schistosome surface

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