Schemes of metabolic patterns of anabolic androgenic steroids for the estimation of metabolites of designer steroids in human urine

@article{Fragkaki2009SchemesOM,
  title={Schemes of metabolic patterns of anabolic androgenic steroids for the estimation of metabolites of designer steroids in human urine},
  author={A. Fragkaki and Y. S. Angelis and A. Tsantili-Kakoulidou and M. Koupparis and C. Georgakopoulos},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2009},
  volume={115},
  pages={44-61}
}
  • A. Fragkaki, Y. S. Angelis, +2 authors C. Georgakopoulos
  • Published 2009
  • Chemistry, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
    • Unified metabolism schemes of anabolic androgenic steroids (AAS) in human urine based on structure classification of parent molecules are presented in this paper. Principal components analysis (PCA) was applied to AAS molecules referred in the World Anti-Doping Agency (WADA) list of prohibited substances, resulting to their classification into six distinct groups related to structure features where metabolic alterations usually occur. The metabolites of the steroids participating to these six… CONTINUE READING
    View on Elsevier
    doi.org
    44 Citations
    Highly Influencial Citations
    1
    Background Citations
    9
    Methods Citations
    2

    Figures, Tables, and Topics from this paper

    Figures and Tables

    Explore Further: Topics Discussed in This Paper

    44 Citations
    Citation Type

    Citation Type

    In Vitro Synthesis of Metabolites of three Anabolic Androgenic Steroids, by Human Liver Microsomes
    ANALYTICAL METHODS FOR THE DETECTION OF NON- LABELED ANABOLIC ANDROGENIC STEROIDS IN FOOD SUPPLEMENTS
    • 1
    Urinary detection of conjugated and unconjugated anabolic steroids by dilute-and-shoot liquid chromatography-high resolution mass spectrometry.
    • 27
    Detection of designer steroid methylstenbolone in “nutritional supplement” using gas chromatography and tandem mass spectrometry: Elucidation of its urinary metabolites
    • 31
    Current status and bioanalytical challenges in the detection of unknown anabolic androgenic steroids in doping control analysis.
    • 14
    Metabolism of methylstenbolone studied with human liver microsomes and the uPA⁺/⁺-SCID chimeric mouse model.
    • 14
    Advances in the detection of designer steroids in anti-doping.
    • 20
    Drug-drug interaction and doping: Effect of non-prohibited drugs on the urinary excretion profile of methandienone.
    • 3
    Statistical analysis of fragmentation patterns of electron ionization mass spectra of enolized-trimethylsilylated anabolic androgenic steroids
    • 32
    Tetrahydrogestrinone analysis and designer steroids revisited.
    • 7

    References

    SHOWING 1-10 OF 45 REFERENCES
    Metabolism of anabolic steroids in man: synthesis and use of reference substances for identification of anabolic steroid metabolites
    • 259
    • Highly Influential
    Metabolism of 4-hydroxyandrostenedione and 4-hydroxytestosterone: Mass spectrometric identification of urinary metabolites
    • 33
    Studies on anabolic steroids—4. Identification of new urinary metabolites of methenolone acetate (primobolan®) in human by gas chromatography/mass spectrometry
    • 28
    Metabolism and excretion of anabolic steroids in doping control—New steroids and new insights
    • P. Eenoo, F. Delbeke
    • Chemistry, Medicine
    • The Journal of Steroid Biochemistry and Molecular Biology
    • 2006
    • 92
    • Highly Influential
    Metabolism of Anabolic-Androgenic Steroids
    • 25
    • PDF
    Studies on anabolic steroids. III. Detection and characterization of stanozolol urinary metabolites in humans by gas chromatography-mass spectrometry.
    • 61
    • PDF
    Gas chromatography/mass spectrometry characterization of urinary metabolites of danazol after oral administration in human.
    • 8
    Discovery, biosynthesis, and structure elucidation of metabolites of a doping agent and a direct analogue, tetrahydrogestrinone and gestrinone, using human hepatocytes.
    • 37
    • PDF
    Studies on anabolic steroids. II--Gas chromatographic/mass spectrometric characterization of oxandrolone urinary metabolites in man.
    • 33
    Metabolites of testosterone: significance in the vital economy
    • 8