Scheduling of Radiation with Angiogenesis Inhibitors Anginex and Avastin Improves Therapeutic Outcome via Vessel Normalization

@article{Dings2007SchedulingOR,
  title={Scheduling of Radiation with Angiogenesis Inhibitors Anginex and Avastin Improves Therapeutic Outcome via Vessel Normalization},
  author={Ruud P M Dings and M. Loren and H. Heun and E. McNiel and A. Griffioen and K. Mayo and R. Griffin},
  journal={Clinical Cancer Research},
  year={2007},
  volume={13},
  pages={3395 - 3402}
}
Purpose: To test whether a direct antiangiogenic peptide (anginex) and a vascular endothelial growth factor antibody (bevacizumab, Avastin) can transiently normalize vasculature within tumors to improve oxygen delivery, alleviate hypoxia, and increase the effect of radiation therapy. Experimental Design: Tumor oxygenation levels, microvessel density and pericyte coverage were monitored in three different solid tumor models (xenograft human ovarian carcinoma MA148, murine melanoma B16F10, and… Expand
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