Scheduled change of antibiotic classes: a strategy to decrease the incidence of ventilator-associated pneumonia.

@article{Kollef1997ScheduledCO,
  title={Scheduled change of antibiotic classes: a strategy to decrease the incidence of ventilator-associated pneumonia.},
  author={Marin H Kollef and Jon J Vlasnik and Linda C. Sharpless and Charles B. Pasque and Deirdre E.M. Murphy and Victoria J. Fraser},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={156 4 Pt 1},
  pages={
          1040-8
        }
}
The purpose of this study was to determine the impact of a scheduled change of antibiotic classes, used for the empiric treatment of suspected gram-negative bacterial infections, on the incidence of ventilator-associated pneumonia and nosocomial bacteremia. Six hundred eighty patients undergoing cardiac surgery were evaluated. During a 6-mo period (i.e., the before-period), our traditional practice of prescribing a third generation cephalosporin (ceftazidime) for the empiric treatment of… CONTINUE READING
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