Schedule specific biochemical modulation of 5-fluorouracil in advanced colorectal cancer: a randomized study. GISCAD, IOR and collaborating centers.

@article{Sobrero2000ScheduleSB,
  title={Schedule specific biochemical modulation of 5-fluorouracil in advanced colorectal cancer: a randomized study. GISCAD, IOR and collaborating centers.},
  author={Alberto F Sobrero and Alberto Zaniboni and Giovanni Luca Frassineti and Carlo Aschele and Alessandra Guglielmi and Rosa Giuliani and Alessandra Ravaioli and Claudio Lanfranco and Cinzia Caroti and Ermenegildo Arnoldi and Sandro Barni and Luigi Gallo and Maria Adelaide Pessi and Daniele Turci and Emil Cortesi and F. Grossi and Luciano Frontini and E. Piazza and Paolo Bruzzi and Roberto Labianca},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2000},
  volume={11 11},
  pages={
          1413-20
        }
}
BACKGROUND We have recently suggested that bolus 5-fluorouracil (5-FU) may work via a RNA directed mechanism while continuous infusion 5-FU may kill cells via a thymidylate synthase related pathway. It may thus be possible to selectively modulate each schedule biochemically. We have compared an alternating regimen of bolus and continuous infusion 5-FU, selectively modulated for the schedule of administration, with modulated bolus 5-FU in advanced colorectal cancer patients. PATIENTS AND… CONTINUE READING

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Colorectal Cancer

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Fluoropyrimidines in Cancer Therapy

  • Cancer Drug Discovery and Development
  • 2002
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CITES METHODS & BACKGROUND
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