Schedule-dependent reversion of cisplatin resistance by 5-fluorouracil in a cisplatin-resistant human lung adenocarcinoma cell line A549DDP.

Abstract

OBJECTIVE To study the schedule-dependent reversion of cis-diamminedichloroplatinum (CDDP) resistance by 5-fluorouracil (5-Fu) in a CDDP resistant human lung adenocarcinoma cell line A549DDP. METHODS Dimethylthiazol dipheryltetrazolium bromide (MTT) assay and immunocytochemistry were used. RESULTS After the A549DDP was treated with CDDP, followed… (More)

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