Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.

@article{Huber2011Sch9RR,
  title={Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.},
  author={Alexandre Huber and Sarah L. French and Hille Tekotte and Seda Yerlikaya and Michael Stahl and Mariya P. Perepelkina and Mike Tyers and Jacques Rougemont and A. L. Beyer and Robbie Loewith},
  journal={The EMBO journal},
  year={2011},
  volume={30 15},
  pages={3052-64}
}
TORC1 is a conserved multisubunit kinase complex that regulates many aspects of eukaryotic growth including the biosynthesis of ribosomes. The TOR protein kinase resident in TORC1 is responsive to environmental cues and is potently inhibited by the natural product rapamycin. Recent characterization of the rapamycin-sensitive phosphoproteome in yeast has yielded insights into how TORC1 regulates growth. Here, we show that Sch9, an AGC family kinase and direct substrate of TORC1, promotes… CONTINUE READING
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