Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis.

@article{Wei2009Sch9PM,
  title={Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis.},
  author={Yuehua Wei and X. F. Steven Zheng},
  journal={Cell cycle},
  year={2009},
  volume={8 24},
  pages={4085-90}
}
TORC1 is a central regulator of ribosomal RNA synthesis. Here we report that Sch9 partially mediates TORC1 signaling to regulate Pol I- and Pol III-dependent transcription. Mechanistically, Sch9 is involved in hyperphosphorylation and cytoplasmic localization of Maf1, and for optimal synthesis of rRNAs and tRNAs. Interestingly, sch9Delta does not affect Maf1 basal phosphorylation and nucleolar localization. In addition, TORC1 is still capable of regulating rRNAs and tRNAs in the absence of Sch9… CONTINUE READING
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