Sch 36605, structure of a novel nucleoside.

@article{Cooper1988Sch3S,
  title={Sch 36605, structure of a novel nucleoside.},
  author={Raymond Cooper and Michael A. Conover and M. C. Patel},
  journal={The Journal of antibiotics},
  year={1988},
  volume={41 1},
  pages={
          123-5
        }
}
A novel nucleoside antibiotic, Sch 36605, has been isolated from the culture filtrate of a Streptomycete sp.;°. All the physico-chemical and spectroscopic data presented herein indicate this compoundis a new blasticidin compound. A second closely related component, Sch 36606, was isolated0 together with Sch 36605. This compoundhas been characterized and identified as leucylblasticidin S2). Sch 36605 (1) is a water soluble basic compound: MP >230°C (dec); [a]2D6 +58.2° (c 0.1, H2O); IR (KBr) cm… 
Sch 36605, a novel anti-inflammatory compound. Taxonomy, fermentation, isolation and biological properties.
A novel anti-inflammatory compound, Sch 36605, belonging to the blasticidin family of nucleoside compounds was isolated from the fermentation filtrate of a Streptomyces sp. Sch 36605, as well as
5′-Hydroxymethyl Cytomycin, a New Nucleoside Antibiotic from Streptomyces sp. HKI-0052
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The structure of the hithero unknown cytosine nucleoside IIb was settled by electrospray CID-MS/MS mass spectrometrical investigations and the new 5′-hydroxymethylcytomycin was introduced.
Reevaluation of the Final Steps in the Biosynthesis of Blasticidin S by Streptomyces griseochromogenes and Identification of a Novel Self-Resistance Mechanism
Abstract The final steps in the biosynthesis of the antifungal peptidyl-nucleoside blasticidin S ( 3 ) have been revised to include a novel self-resistance mechanism wherein the previously proposed
Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.
TLDR
The discovery and potential applications of structurally complex pyrimidine nucleoside antibiotics for which genetic information is known are highlighted, the established reactions that convert the canonical pyridine into a new nucleosid scaffold are established, and the important tailoring reactions that impart further structural complexity to these molecules are highlighted.
Current progress on nucleoside antibiotics.
  • K. Isono
  • Chemistry, Medicine
    Pharmacology & therapeutics
  • 1991
TLDR
Structure and biological activity of thirty-six new nucleoside antibiotics which appeared after the 1988 review are described, with special emphasis on their antiviral activities.
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TLDR
The expansion of the biological role for PepN in antibiotic maturation and the first report of hydrolysis of beta amide linkage by this conserved enzyme are presented.
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This chapter reviews polyoxins and related nucleosides, which have highly modified bases, sugars and amino acids, and they have complex biosynthetic pathways; the sequence of reactions proposed for polyoxin formation would require more than a dozen enzymes.
Cytosylglucuronic acid synthase (cytosine: UDP-glucuronosyltransferase) from Streptomyces griseochromogenes, the first prokaryotic UDP-glucuronosyltransferase
TLDR
Cytosylglucuronic acid synthase (cytosine: UDP-glucuronosyltransferase), the first prokaryotic UDP-GT and a key enzyme in the biosynthesis of the antibiotic blasticidin S, was purified 870-fold and was strongly inhibited by UDP.
Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S
TLDR
Experiments demonstrated that LDBS is indeed an intermediate in BS biosynthetic pathway, and acylation of beta-amino group of arginine side chain is prerequisite for efficient guanidine N-methylation in addition to being a self-resistance mechanism.
Some Aspects of Guanidine Secondary Metabolites
Guanidine natural products have been the subject of several reviews (1–12). More recently, Mori (8,9) has discussed many aspects of natural guanidine derivatives, Chevolot (10) has focused on
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Sch 36605, a novel anti-inflammatory compound. Taxonomy, fermentation, isolation and biological properties.
A novel anti-inflammatory compound, Sch 36605, belonging to the blasticidin family of nucleoside compounds was isolated from the fermentation filtrate of a Streptomyces sp. Sch 36605, as well as
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