Scd6 targets eIF4G to repress translation: RGG motif proteins as a class of eIF4G-binding proteins.

@article{Rajyaguru2012Scd6TE,
  title={Scd6 targets eIF4G to repress translation: RGG motif proteins as a class of eIF4G-binding proteins.},
  author={Purusharth Rajyaguru and Meipei She and Roy Parker},
  journal={Molecular cell},
  year={2012},
  volume={45 2},
  pages={244-54}
}
The formation of mRNPs controls the interaction of the translation and degradation machinery with individual mRNAs. The yeast Scd6 protein and its orthologs regulate translation and mRNA degradation in yeast, C. elegans, D. melanogaster, and humans by an unknown mechanism. We demonstrate that Scd6 represses translation by binding the eIF4G subunit of eIF4F in a manner dependent on its RGG domain, thereby forming an mRNP repressed for translation initiation. Strikingly, several other RGG domain… CONTINUE READING