Scavenger receptors of endothelial cells mediate the uptake and cellular proatherogenic effects of carbamylated LDL.

@article{Apostolov2009ScavengerRO,
  title={Scavenger receptors of endothelial cells mediate the uptake and cellular proatherogenic effects of carbamylated LDL.},
  author={Eugene O. Apostolov and Sudhir V. Shah and Debarti Ray and Alexei G. Basnakian},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 10},
  pages={1622-30}
}
OBJECTIVE Carbamylated LDL (cLDL) has been recently shown to have robust proatherogenic effects on human endothelial cells in vitro, suggesting cLDL may have a significant role in atherosclerosis in uremia. The current study was designed to determine which receptors are used by cLDL and thus cause the proatherogenic effects. METHODS AND RESULTS In ex vivo or in vitro models as well as in intact animals, administration of cLDL was associated with endothelial internalization of cLDL and… CONTINUE READING

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