Scavenger-receptor targeted photodynamic therapy.

@article{Hamblin2000ScavengerreceptorTP,
  title={Scavenger-receptor targeted photodynamic therapy.},
  author={Michael R Hamblin and Jennifer Louise Miller and Bernhard J Ortel},
  journal={Photochemistry and photobiology},
  year={2000},
  volume={72 4},
  pages={
          533-40
        }
}
Covalent conjugation of a photosensitizer to a ligand that specifically recognized and internalized by a cell-surface receptor may be a way of improving the selectivity of photodynamic therapy (PDT). The class A Type-I scavenger receptor of macrophages, which among other ligands recognizes maleylated serum albumin and has a high capacity is a good candidate for testing this approach. Chlorin(e6) was covalently attached to bovine serum albumin to give conjugates with molar substitution ratios of… CONTINUE READING

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