Scavenger receptor class B type I: a multifunctional receptor

  title={Scavenger receptor class B type I: a multifunctional receptor},
  author={Giuseppe Valacchi and Claudia Sticozzi and Yunsook Lim and Alessandra Pecorelli},
  journal={Annals of the New York Academy of Sciences},
The scavenger receptor class B type I (SR‐B1) plays an important role in meditating the uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR‐B1 does this is unclear. Other than its role as an HDL receptor, SR‐B1 is also involved in pathogen recognition; its expression can be modulated by lipopolysaccharide and oxidative… 
Scavenger receptor Class B type I as a potential risk stratification biomarker and therapeutic target in cardiovascular disease
The aim of the current review was to provide an overview of the possible molecular mechanisms by whichSR‐BI may affect CVD risk, and the clinical implications of this, with particular emphasis on preclinical studies on genetic changes of SR‐BI and CVDrisk.
Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer
The reduction in cellular cholesterol availability can impede prostate cancer proliferation through both decreased steroid synthesis and steroid-independent mechanisms, providing a potential therapeutic target for the treatment of prostate cancer.
Scavenger receptor B1 post‐translational modifications in Rett syndrome
Exploiting scavenger receptors in cancer immunotherapy: Lessons from CD5 and SR‐B1
This review focuses on the regulation of the anti‐tumor immune response by two paradigmatic SRs: the lymphocyte receptor CD5 and the more broadly distributed scavenger receptor class B type 1 (SR‐B1).
Nanoparticle Targeting and Cholesterol Flux Through Scavenger Receptor Type B-1 Inhibits Cellular Exosome Uptake
Exosomes are nanoscale vesicles that mediate intercellular communication. Cellular exosome uptake mechanisms are not well defined partly due to the lack of specific inhibitors of this complex
A novel role for scavenger receptor B1 as a contributor to the capture of specific volatile odorants in the nasal cavity.
A novel role for SR-B1 is uncovered as a contributor to the capture of specific odorants in the nasal cavity of mammals through recognition of aliphatic aldehydes as potential ligands.
Xinxuekang Regulates Reverse Cholesterol Transport by Improving High-density Lipoprotein Synthesis, Maturation, and Catabolism.
This is the first study to show that XXK confers a regulation of RCT, at least in part, by improving HDL synthesis, maturation, and catabolism.


Scavenger Receptor Class B Type I as a Mediator of Cellular Cholesterol Efflux to Lipoproteins and Phospholipid Acceptors*
Studies that suggest that the presence of phospholipid on acceptor particles plays an important role in modulating interaction with the SR-BI are described, which may help to explain observations in the literature that document an increased risk of atherosclerosis in patients with depressed levels of HDL phospholIPid even in the face of normal HDL cholesterol levels.
Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein.
A potential function of SR-BI is demonstrated, in addition to its role in selective uptake of lipids, to mediate internalization of OxLDL by macrophages and suggest a central role for oxidized phospholipids in this process.
Scavenger Receptor Class B Type I (SR-BI) Is Involved in Vitamin E Transport across the Enterocyte*
The present data show for the first time that vitamin E intestinal absorption is, at least in part, mediated by SR-BI.
Scavenger Receptor Class B Type I Mediates the Selective Uptake of High-Density Lipoprotein–Associated Cholesteryl Ester by the Liver in Mice
Objective— High-density lipoprotein (HDL) cholesteryl esters (CE) are taken up by liver and adrenals selectively, ie, independent from particle internalization. Class B type I scavenger receptor
Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells.
It is shown that vitamin E (vitE) has a major effect on the expression of SR-BI in rat liver and in a human hepatoma-derived cell line, HepG2, and the inhibitory effect of vitE on PKC seems to be involved in the signaling pathway.
Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice.
It is shown that the scavenger receptor class B type I (SR-BI), which mediates cellular selective cholesteryl ester uptake from lipoproteins, facilitates efficient transfer of alpha-T from HDL to cultured cells.
Scavenger receptor class B type I affects cholesterol homeostasis by magnifying cholesterol flux between cells and HDL.
Results from several laboratories clearly indicate that expression of scavenger receptor class B type I (SR-BI) enhances the bidirectional flux of cholesterol between cells and lipoproteins, and the level of SR-BI expression determines both the rate of free cholesterol flux and the steady state level of cellular cholesterol.
Scavenger Receptor Class B Type I-mediated Cholesteryl Ester-selective Uptake and Efflux of Unesterified Cholesterol
It is suggested that binding induces an optimal alignment of the WT apoA-I·SR-BI complex so that the efficiency of lipid transfer is always the same and that FC efflux to HDL is affected both by binding of HDL to SR-BI and by the ability of the receptor to perturb the packing of FC molecules in the cell plasma membrane.
Scavenger receptor BI: A scavenger receptor with a mission to transport high density lipoprotein lipids
It will be interesting to follow future research on scavenger receptor BI that will delineate its functions in cholesterol transport as well as its scavenger functions.