Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity.

@article{Grove2007ScavengerRB,
  title={Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity.},
  author={Joe Grove and Thierry Huby and Zania Stamataki and Thomas Vanwolleghem and Philip Meuleman and Michelle J. Farquhar and Anne K Schwarz and Martine Moreau and James Stuart Owen and Geert Leroux-Roels and Peter Balfe and Jane A McKeating},
  journal={Journal of virology},
  year={2007},
  volume={81 7},
  pages={3162-9}
}
Hepatitis C virus (HCV) enters cells via a pH- and clathrin-dependent endocytic pathway. Scavenger receptor BI (SR-BI) and CD81 are important entry factors for HCV internalization into target cells. The SR-BI gene gives rise to at least two mRNA splice variants, SR-BI and SR-BII, which differ in their C termini. SR-BI internalization remains poorly understood, but SR-BII is reported to endocytose via a clathrin-dependent pathway, making it an attractive target for HCV internalization. We… CONTINUE READING