Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface.

@article{LleraMoya1999ScavengerRB,
  title={Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface.},
  author={Margarita de la Llera-Moya and George H. Rothblat and Margery A. Connelly and Ginny Kellner-Weibel and S W Sakr and Michael C Phillips and David L Williams},
  journal={Journal of lipid research},
  year={1999},
  volume={40 3},
  pages={575-80}
}
In addition to its effect on high density lipoprotein (HDL) cholesteryl ester (CE) uptake, scavenger receptor BI (SR-BI) was recently reported to stimulate free cholesterol (FC) flux from Chinese hamster ovary (CHO) cells stably expressing mouse SR-BI, a novel function of SR-BI that may play a role in cholesterol removal from the vessel wall where the receptor can be found. It is possible that SR-BI stimulates flux simply by tethering acceptor HDL particles in close apposition to the cell… CONTINUE READING