Scavenger receptor BI: A scavenger receptor with a mission to transport high density lipoprotein lipids

@article{Connelly2004ScavengerRB,
  title={Scavenger receptor BI: A scavenger receptor with a mission to transport high density lipoprotein lipids},
  author={Margery A. Connelly and David L. Williams},
  journal={Current Opinion in Lipidology},
  year={2004},
  volume={15},
  pages={287-295}
}
Purpose of review This review will survey recent findings on the cholesterol transport and scavenger functions of scavenger receptor BI. Although scavenger receptor BI and CD36 bind many of the same ligands, these two receptors have very specific lipid transport functions: CD36 facilitates the uptake of long chain fatty acids and SR-BI mediates the transport of cholesterol and cholesteryl ester from HDL particles. Scavenger receptor BI is a physiologically relevant HDL receptor that, along with… 
Specific Oxidized Phospholipids Inhibit Scavenger Receptor BI-mediated Selective Uptake of Cholesteryl Esters*
TLDR
OxPCCD36 prevent binding to SR-BI of its physiological ligand, high density lipoprotein, because of the close proximity of the binding sites for these two ligands onSR-BI, which may have an inhibitory effect on reverse cholesterol transport.
Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function
TLDR
Characteristics of the selective uptake pathway and involvement of microvillar channels as facilitators of selective HDL-CE uptake are summarized and the potential mechanisms of SR-B1-mediated selective cholesterol transport are presented.
Current understanding of the metabolism and biological actions of HDL
TLDR
Properties with respect to cytokine production, lipid oxidation, cholesterol efflux and reverse cholesterol transport make HDL a protective agent and thus an interesting therapeutic target in atherosclerosis and inflammation-induced organ damage.
Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP‐binding cassette transporter g5/g8 in mice
TLDR
It is indicated that SR‐BI mediates biliary cholesterol secretion independent of Abcg5, yet largely depends on Abcb4‐mediated phospholipid secretion and mixed micelles as acceptors in bile.
Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages
TLDR
The presence of distinct pathways for cholesterol efflux to lipid-free apolipoprotein AI and phospholipid-containing HDL species clarifies the understanding of reverse cholesterol transport, and provides new opportunities for its therapeutic manipulation.
New insights into the regulation of cellular cholesterol efflux and high-density lipoprotein metabolism
TLDR
This work presents accumulating evidence that other molecules, such as ABCG1 and scavenger receptor class B type I, also play a pivotal role in cholesterol efflux and HDL metabolism.
Novel biological functions of high-density lipoprotein cholesterol.
TLDR
Ass assessments of these functions of HDL are now being applied to patient populations to better-elucidate which actions of HDL may contribute to its cardioprotective potential and how they can be quantified and targeted.
SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies.
TLDR
The scavenger receptor B class type 1 (SR-B1) was identified as the high-affinity HDL receptor, which facilitates the selective uptake of cholesterol ester into the liver via HDL and is also implicated in the plasma clearance of LDL, very low-density lipop protein (VLDL) and lipoprotein(a) (Lp(a)).
...
...

References

SHOWING 1-10 OF 129 REFERENCES
Scavenger Receptor Class B Type I as a Mediator of Cellular Cholesterol Efflux to Lipoproteins and Phospholipid Acceptors*
TLDR
Studies that suggest that the presence of phospholipid on acceptor particles plays an important role in modulating interaction with the SR-BI are described, which may help to explain observations in the literature that document an increased risk of atherosclerosis in patients with depressed levels of HDL phospholIPid even in the face of normal HDL cholesterol levels.
Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface.
TLDR
The results showed that SR-BI mediates alterations to membrane FC domains which provoke enhanced bidirectional FC flux between cells and extracellular acceptors, and shows that the major stimulation of FC efflux occurs independently of acceptor binding to cell surface receptors.
Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein.
TLDR
A potential function of SR-BI is demonstrated, in addition to its role in selective uptake of lipids, to mediate internalization of OxLDL by macrophages and suggest a central role for oxidized phospholipids in this process.
Analysis of chimeric receptors shows that multiple distinct functional activities of scavenger receptor, class B, type I (SR-BI), are localized to the extracellular receptor domain.
TLDR
Results show that multiple distinct functional activities related to HDL CE selective uptake, bi-directional FC flux, and the alteration of membrane cholesterol mass and distribution are localized to the SR-BI extracellular domain.
Comparison of Class B Scavenger Receptors, CD36 and Scavenger Receptor BI (SR-BI), Shows That Both Receptors Mediate High Density Lipoprotein-Cholesteryl Ester Selective Uptake but SR-BI Exhibits a Unique Enhancement of Cholesteryl Ester Uptake*
TLDR
The results show that the extracellular domain of mSR-BI is essential for efficient HDL CE uptake, but the C-terminal cytoplasmic tail also has a major influence on the selective uptake process.
Scavenger receptor BI--a cell surface receptor for high density lipoprotein.
TLDR
This work reviews recent studies of the class B, type I scavenger receptor, which appears to be a physiologically relevant, cell surface HDL receptor that mediates the selective uptake of lipids by cells.
Transport of Lipids from High and Low Density Lipoproteins via Scavenger Receptor-BI*
TLDR
Data indicate that SR-BI is able to exchange cholesterol rapidly between lipoproteins and cell membranes and can mediate the uptake of cholesteryl esters from both classes of lipoprotein, but HDL was a more effective donor.
Scavenger receptor class B type I in high-density lipoprotein metabolism, atherosclerosis and heart disease: lessons from gene-targeted mice.
TLDR
Bone-marrow transplantation is used to demonstrate that bone- marrow-derived SR-BI also normally protects against atherosclerosis in low-density lipoprotein receptor knockout mice, suggesting that SR- BI may have multiple protective effects against atheOSclerosis in different tissues.
The cellular biology of scavenger receptor class B type I
TLDR
Scavenger receptor class B type I expression has been shown to alter plasma membrane cholesterol distribution and induce the formation of novel membrane structures, suggesting multiple roles for scavenger receptorclass Btype I in the cell.
...
...