Scavenger receptor B2 is a cellular receptor for enterovirus 71

@article{Yamayoshi2009ScavengerRB,
  title={Scavenger receptor B2 is a cellular receptor for enterovirus 71},
  author={Seiya Yamayoshi and Yasuko Yamashita and Jifen Li and Nobutaka Hanagata and Takashi Minowa and Taro Takemura and Satoshi Koike},
  journal={Nature Medicine},
  year={2009},
  volume={15},
  pages={798-801}
}
Enterovirus 71 (EV71) belongs to human enterovirus species A of the genus Enterovirus within the family Picornaviridae. EV71, together with coxsackievirus A16 (CVA16), are most frequently associated with hand, foot and mouth disease (HFMD). Although HFMD is considered a mild exanthematous infection, infections involving EV71, but not CVA16, can progress to severe neurological disease, including fatal encephalitis, aseptic meningitis and acute flaccid paralysis. In recent years, epidemic and… 
[Identification of an enterovirus 71 receptor; SCARB2].
TLDR
A human gene, scavenger receptor B2 (SCARB2), integrated in one of the transformant cells by microarray analysis and showed that SCARB2 can serve as a EV71 receptor, which is considered to be a neuropathogenic virus.
Receptors for enterovirus 71
TLDR
The three-dimensional structures of the mature EV71 virion, procapsid and empty capsid, as well as the exofacial domain of SCARB2, have been elucidated and greatly increased the understanding of the early steps of EV71 infection.
Cellular receptors for enterovirus A71
TLDR
Although heparan sulfate proteoglycans are expressed by many cultured cell lines and enhance infection by a subset of EV-A71 strains, they are not expressed by cells that express SCARB2 at high levels in vivo and do not contribute to replication or dissemination of the virus in vivo.
Human SCARB2-Mediated Entry and Endocytosis of EV71
TLDR
The mechanism of EV71 entry through SCARB2 as the receptor for attachment, and its cellular entry is through a clathrin-mediated and pH-dependent endocytic pathway is useful for the development of effective medications and prophylactic treatment against the enterovirus.
Human SCARB2-Dependent Infection by Coxsackievirus A7, A14, and A16 and Enterovirus 71
TLDR
It was shown that all 162 clinical isolates of EV71 propagated in L-SCARB2 cells, suggesting that SCARB2 is the critical receptor common to all EV71 strains.
Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2
TLDR
The structure of enterovirus 71 in complex with its receptor SCARB2 provides insights into the mechanism of viral uncoating within the endo/lysosome compartment and identifies few conserved key residues within the binding footprint that might facilitate the design of receptor mimic therapeutics.
Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18
TLDR
The findings reveal that FcRn is a two-in-one attachment-uncoating receptor for E18, which is a significant causative agent of aseptic meningitis and viral encephalitis in children and one of the most commonly reported syndromes associated with E18.
Antiviral activity of acid beta-glucosidase 1 on enterovirus 71, a causative agent of hand, foot and mouth disease.
TLDR
A cDNA library screen and identified acid β-glucosidase 1 (GBA1) as an EV71 resistance factor suggest that GBA1 may represent a novel molecular target for the treatment of EV71 infection.
Cell and tissue tropism of enterovirus 71 and other enteroviruses infections
TLDR
A summary of host and virus factors affecting cell and tissue tropism and the pathogenesis of enteroviruses is provided.
Scavenger Receptor B2 as a Receptor for Hand, Foot, and Mouth Disease and Severe Neurological Diseases
TLDR
Several lines of evidence suggest that scavenger receptor class B, member 2 (SCARB2) plays critical roles in efficient EV71 infection and the development of disease in humans.
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