Scavenger receptor-AI-targeted iron oxide nanoparticles for in vivo MRI detection of atherosclerotic lesions.

@article{Segers2013ScavengerRI,
  title={Scavenger receptor-AI-targeted iron oxide nanoparticles for in vivo MRI detection of atherosclerotic lesions.},
  author={Filip M E Segers and Brigit den Adel and Ilze Bot and Linda M van der Graaf and Eric P. van der Veer and Walter Gonzalez and Isabelle Raynal and Menno P J de Winther and Will K. W. H. Wodzig and Robert E. Poelmann and Theo J. C. van Berkel and Louise van der Weerd and Erik Anna Leonardus Biessen},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 8},
  pages={1812-9}
}
OBJECTIVE In search of molecular imaging modalities for specific detection of inflammatory atherosclerotic plaques, we explored the potential of targeting scavenger receptor-AI (SR-AI), which is highly expressed by lesional macrophages and linked to effective internalization machinery. APPROACH AND RESULTS Ultrasmall superparamagnetic iron oxide particles were conjugated to a peptidic SR-AI ligand (0.371 mol Fe/L and 0.018 mol PP1/L). In vitro incubation of human or murine macrophages with SR… CONTINUE READING