Scattered Hammond plots reveal second level of site-specific information in protein folding: phi' (beta++).

@article{Hedberg2004ScatteredHP,
  title={Scattered Hammond plots reveal second level of site-specific information in protein folding: phi' (beta++).},
  author={Linda Johansson Hedberg and Mikael Oliveberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 20},
  pages={7606-11}
}
Site-specific information about structural heterogeneities of the protein-folding transition-state ensemble is commonly derived from the scatter of the Brønsted plot through the individual values of = Delta logk(f)/Delta logK(D-N). Here, we provide a second level of site-specific detail in the transition-state analysis by demonstrating that the scatter of the Hammond plot is related to heterogeneities in the -value growth. That is, the extent of transition-state movement (Delta beta(++)) is… CONTINUE READING

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Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding (Freeman, New York)

  • A. R. Fersht
  • 1999

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