Scanning force microscopy of nucleic acid complexes.

  title={Scanning force microscopy of nucleic acid complexes.},
  author={Peter T. Lillehei and Lawrence A Bottomley},
  journal={Methods in enzymology},
SFM is a viable effective method for determining the mode of binding, the extent of binding, and the site of binding of intercalators to nucleic acids. Establishing the presence of a groove-bound ligand can be achieved either by competitive binding experiments with a well-defined intercalator (minor groove) or by changes in apparent contrast (major groove). In our opinion, SFM has an important role in resolving the structural polymorphisms for small molecule-DNA complexes. Application of these… CONTINUE READING
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